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The three types of diet pills the FDA has approved are Orlistat (Xenical), Sibutramine (Meridia) and sympathomimetic appetite suppressants (Phentermine). Ask your health care provider which type of diet pill would work best for you. In 2012, the FDA approved the first two new weight loss drugs in over a decade: Qsymia ( phentermine and topiramate) is from Vivus Pharmaceuticals. In clinical trials, Qsymia weight loss was on average 8.9% greater than for those taking placebo. Belviq ( lorcaserin) is from Eisai Pharmaceuticals. 5 Weight Loss Drugs Approved by FDA Orlistat. A lipase inhibitor (fat blocker), Orlistat causes less fat (30 percent of fat and calories) to be absorbed Phentermine and Topiramate. This drug combines two FDA-approved medications—phentermine and topiramate—in an Lorcaserin Hydrochloride. This The table below lists FDA-approved prescription medications for weight loss. The FDA has approved five of these drugs—orlistat (Xenical, Alli), lorcaserin (Belviq), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and liraglutide (Saxenda)—for long-term use. Keto Pills FDA Approved The supplement works its magic on its own and shows results within weeks. It does not require any kind of exterior effort, for example, weight loss or going to the gym. All it calls for is to be taken consistently, and rest assured it will certainly drop pounds off the body in a snap.